Davinson Sanchez and Tanguy Ndombele have fallen completely out of favour at Spurs and have been available for transfer this summer.
They are set to remain teammates, but no longer at Tottenham, with Galatasaray agreeing deals for both men.
Ndombele is set to join the Turkish giants on a loan deal, with an option to buy at the end of the short-term contract, while Sanchez is moving on a permanent transfer.
The centre-back is set to cost around £12.8m, bringing to an end a six-year stint at Spurs after joining from Ajax for £42m in 2017.
Ndombele has been at Spurs since 2019 but has already spent loan spells out at Lyon and Napoli after failing to find top form in north London after costing a club record fee of £55.45m.
Galatasaray are in a hurry to complete the deals and register the players as that must be done by 11pm UK time on Monday for them to be included in their Champions League squad for the group stages.
It has been a busy summer in the transfer market already for Galatasaray, already bringing in the likes of Wilfried Zaha, Mauro Icardi and Kerem Demirbay.
They secured a group stage spot in the Champions League after beating Molde in the last qualifying round and will take on Manchester United, Copenhagen and Bayern Munich in their group.
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